1% ointment to a clean, dry, and
Careful and frequent monitoring of tacrolimus trough concentrations is recommended; Black patients may require higher doses in order to achieve comparable trough
Increase tacrolimus dose and monitor tacrolimus whole blood trough concentrations [s ee Dosage and Administration (2
On This Page Indications and Usage Dosage and Administration Dosage Forms and Strengths Contraindications Warnings and
Lower tacrolimus dosages than the recommended initial dosage may be sufficient as maintenance therapy
Neurological symptoms (tremor, headache) • Assess tacrolimus trough level for correlation with tremors or headache • If trough level is above goal, adjust tacrolimus
03% ointment: Apply a thin layer to the affected areas 2 times a day and rub in gently and completely; discontinue use when symptoms resolve
• The 0
Because this is a renal transplant patient, a dose in the lower end of the range (0
Measure tacrolimus whole blood trough concentrations at least two times on separate days during the first week after initiation of dosing and after a change in dosage, after a change in co-administration of CYP3A4 inducers and/or inhibitors or cannabidiol [see Drug Interactions (7
m
075 mg/kg/day to 0
050 mg/kg BD and a target level of 5 μg/L (range of 3–7 μg/L)
In the voriconazole arm - Rx interactions of immunosuppressants in solid-organ transplants - Cytochrome P450 3A inhibitors and inducers - Glucocorticoid dosing for patients after liver transplant - Criteria for acute kidney injury - Definition and criteria for CKD - Tacrolimus levels for adult liver transplant recipients - Cyclosporine and tacrolimus preparations -
075 mg/kg/day] on a mg/m 2 basis) or 3 mg/kg/day (2
1 mg/kg per day), had a peak milk level of 0
5–2 ng/mL), the two most widely used assays for the drug use blood samples
8 to 6
4 times the recommended clinical dose range), resulted in a dose-related decrease in sperm count
Increasing tacrolimus time-in-therapeutic range is associated with superior one-year outcomes in lung transplant recipients
Table 1
Tacrolimus, subcutaneously administered to male rats at paternally toxic doses of 2 mg/kg/day (1
4 to 6
2 mg/kg once daily prior to reperfusion or within 48 hours of completion time to achieve tacrolimus steady state is approximately 7 days after initiating or changing the ASTAGRAF XL dose
The drug can also be sold as a topical medication in the treatment of T-cell-mediated diseases such as eczema and
Adult liver transplantation: UK clinical guideline – part 2: surgery and post-operation
The capsules should be taken whole (not crushed or chewed) on an empty stomach